NANO-BIO-IMAGING & DEVICES LABORATORY


About the Lab

At the Lal Nano-Bio-Imaging and Devices Laboratory, we have two large thrusts in basic science and enabling technology development centered on our expertise in multiscale imaging and mechanics  with atomic force microscope (AFM). In parallel, we specialize in nanosensors and devices, including controlled on-demand theranostic delivery.

In the past we have used the AFM-based multi modality imaging and functional mapping to study protein misfolding, cell-cell and cell-surroundings interactions. We also hope to further improve upon AFM design and application. By these efforts our goal is make AFM a common-place technology useful in the study of normal and pathophysiology, formation of preventive strategies, and characterization of therapeutics among other things. Recently we have expanded our capabilities in nanomaterial based carriers for biological applications.

Professor Lal

Professor Lal is Professor of Bioengineering, Mechanical Engineering, Material Science & Engineering, and Co-Director of Center for Excellence in Nanomedcine and Engineering at UC San Diego. 
He received his MS and Masters of Philosophy in Physics and Biophysics from JNU in New Delhi and his Ph.D. in Neurobiology from the University of Alabama. After postdoctoral training at Caltech, he was a faculty member at the University of Chicago and the University of California at Santa Barbara. Before accpeting his current position at UCSD, he was a Professor and the Director of the newly established Center of Nanomedicine at the University of Chicago. 
He is a Fellow of AAAS (the American Association for Advancement of Science) and a Fellow of the American Institute of Medical and Biological Engineering (AIMBE). He was a visiting professor at the Chinese Academy of Sciences, Institute for Applied Physics, Shanghai. Before, he was the UTS Invited Professor in Sydney for the Bionanotechnology initiative and a New Zealand Government International Science Scholar.

Professor Lal is an Associate Editor of the Journal Nanomedicine: Nanotechnology, Biology, Medicine. He is the Chairman of American Nanosolutions, LLC, Vessel ANI, Inc and is on advisory board of RC Nano LLC and Be Green Packaging LLC. 

Professor Lal served on the NIH Nano study section. In addition to seminal research publications in the field of nanomedicine, he holds several patents based upon AFM cantilever arrays, microfluidics, optoelectronics and nanotubes for medical diagnostics and medical nanodevices, nanoscale fluid behavior and new TIRF, FRET and related optical microscopy.

Recent Announcements

  • September News!
    Congratulations to Grace, Deependra, Vrinda, Jay Seth, Sami, Nirav, Qingqing, and Joon for their new publication!

    • Wang L.*, Jang G.*, Ban D.*, Sant V.*, Seth J., Kazmi S., Patel N., Yang Q., Lee J., Janetanakit W., Wang S., Head B., Glinsky G, Lal R. Multifunctional Stimuli Responsive Polymer-Gated Iron and Gold-Embedded Silica Nano Golf Balls: Nanoshuttles for Targeted On-Demand Theranostics Nature Bone Research 2017 (Accepted) 

    • Hernandez A.M.*, Urbanke H.*, Gillman A.*, Lee J.*, Ryazanov S., Agbemenyah H.Y., Benito E., Jain G., Kaurani L., Grigorian G., Leonov A., Rezaei-Ghaleh N., Wilken P., Arce F.T., Wagner J., Fuhrman M., Caruana M., Camilleri A., Vassallo N., Zweckstetter M., Benz R., Giese A., Schneider A., Korte M.#Lal R.#, Griesinger C.#, Eichele G.#, Fischer A.# The diphenylpyrazol compound anle138b blocks Abeta channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 2017 (Accepted) 

    • Wang Z., Luo Y., Xie X., Hu X., Song H., Zhao Y., Shi J., Wang L., Glinsky G., Chen N., Lal R., Fan C. In-situ Spatial Complementation of Aptamer-mediated Recognition Enables Live-cell Imaging of Native RNA Transcripts in Real Time Angewandte Chemie 2017 doi: 10.1002/anie.201707795
    Posted Sep 25, 2017, 3:59 PM by Joon Lee
  • August News!
    Congratulations to Michael for his new publication!!

    Song P., Ye D., Zuo X., Li J., Wang J., Liu H., Hwang M. T., Chao J., Su S., Wang L., Shi J., Wang L., Huang W., Lal R., Fan, C. DNA Hydrogel with Aptamer-Toehold Based Recognition, Cloaking and Decloaking of Circulating Tumor Cells for Live Cell Analysis. Nano Lett. 2017. doi: 10.1021/acs.nanolett.7b01006
    Posted Aug 3, 2017, 2:52 PM by Joon Lee
  • July News!
    Congratulations to Nirav, Grace, Malvika, Sami, Deependra for their new publication!

    Janetanakit W., Wang L., Santacruz-Gomez K., Landon, P. B., Sud P. L., Patel N., Jang G., Jain M., Yepremyan A., Kazmi S., A., Ban D.K., Zhang F., and Lal R. Gold Embedded Hollow Silica Nano Golf Balls for Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017. doi: 10.1021/acsami.7b08398
    Posted Aug 3, 2017, 2:51 PM by Joon Lee
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