At the Lal Nano-Bio-Imaging and Devices Laboratory, we have two large thrusts in basic science and enablingtechnology development centered on our expertise in multiscaleimaging and mechanics with atomic force microscope (AFM). In parallel, we specialize in nanosensors and devices, including controlled on-demand theranostic delivery
In the past we have used the AFM-based multi modality imaging and functional mapping to study protein misfolding, cell-cell and cell-surroundings interactions. We also hope to further improve upon AFM design and application. By these efforts our goal is make AFM a common-place technology useful in the study of normal and pathophysiology, formation of preventive strategies, and characterization of therapeutics among other things. Recently we have expanded our capabilities in nanomaterial based carriers for biological applications
Congratulations to Alan Gillman, Joon Lee, Nirave Patel, Alex Mo, Preston Landon, Woraphong Janetanakit, Michael Hwang, Karla Santacruz Gomez, David Alex Colburn, Samuel Dossou, Vrinda Sant, Paul Sud, Sid Akkiraju and Chen Zhangon their amazing work on these following publications in the first half of 2016!
Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. Computational Methods for Structural and Functional Studies of Alzheimer’s Amyloid Ion Channels. Protein Amyloid Aggregation: Methods and Protocols. 2016:251-68. DOI: 10.1007/978-1-4939-2978-8_16
Feinstein HE, Benbow SJ, LaPointe NE, Patel N, Ramachandran S, Do TD, Gaylord MR, Huskey NE, Dressler N, Korff M, Quon B. Cantrell KL, Bowers MT, Lal R, and Feinstein SC. Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action. Journal of neurochemistry. 2016 Apr 1. DOI: 10.1111/jnc.13604
Mo AH, Zhang C, Landon PB, Janetanakit W, Hwang MT, Santacruz Gomez K, Colburn DA, Dossou SM, Lu T, Cao YB, Sant V. Sud P, Akkiraju S, Shubayev V, Glinsky G, and Lal R.Dual-functionalized Theranostic Nanocarriers. ACS Applied Materials & Interfaces. 2016 May 4. DOI: 10.1021/acsami.6b02761
Mo AH, Landon P, Gomez KS, Kang H, Lee J, Zhang C, Janetanakit W, Sant V, Lu T, Colburn DA, Akkiraju S. Dossou S., Cao Y., Lee K, Varghese S,Glinsky G and Lal R.Magnetically-responsive Silica-gold Nanobowls for targeted delivery and SERS-based sensing. Nanoscale. 2016. DOI: 10.1039/C6NR02445A
Hwang, M. T.; Landon, P. B.; Lee, J.; Choi, D.; Mo, A. H.; Glinsky, G.; Lal, R. Highly Specific SNP Detection Using 2D Graphene Electronics and DNA Strand Displacement. Proc. Natl. Acad. Sci. 2016. Doi: 10.1073/pnas.1603753113 (for press release, check here)