At the Lal Nano-bio-imaging and Devices Laboratory, we have two large thrusts in basic science and enablingtechnology development centered on our expertise in multiscaleimaging and mechanics with atomic force microscope (AFM). In parallel, we specialize in nanosensors and devices, including controlled on-demand theranostic delivery
In the past we have used the AFM-based multi modality imaging and functional mapping to study protein misfolding, cell-cell and cell-surroundings interactions. We also hope to further improve upon AFM design and application. By these efforts our goal is make AFM a common-place technology useful in the study of normal and pathophysiology, formation of preventive strategies, and characterization of therapeutics among other things. Recently we have expanded our capabilities in nanomaterial based carriers for biological applications
Congratulations to Prof. Lal on his induction into the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. The AIMBE has recongized Prof Lal for "applications of atomic force microscopy for nanoscale biophysical and biochemical understanding of membrane protein structures, protein misfolding diseases and nanomedicine." Prof Lal was formally inducted at a ceremony in Washington, D.C. and AIMBE's 2015 Annual Meeting in March. For more information, click here.
We have published 4 more papers this fall and are excited to share them.
1. Preston Landon, Joon Lee, Michael Hwang, Alexander Mo, and Brian Meckes contributed to the work on improving the kinetics of DNA strand displacement using inosine substitutions in the DNA strand. The work is entitled Energetically Biased DNA Motor Containing a Thermodynamically Stable Partial Strand Displacements State" and is published in Langmuir. 2. Brian Meckes and Fernando Arce studied the formation of connexin26 hemichannels in purified membranes with AFM. The full work is entitled "Atomic Force Microscopy Shows Connexin26 Hemichannel Clustering in Purified Membrane Fragments" and is published in Biochemistry. 3. Alexander Mo, Preston Landon, Chris Emerson,Siddartha Akkiraju, and Paula Anzenberg have developed a method produce to silica nanobowls from spontaneously formed silica nanoparticles partially encapsulating smaller polystyrene. The full work is entitled "Synthesis of Nano-Bowls with a Janus Template" and is published in Nanoscale. 4. Former visiting PhD student Raffella Fior andcurrent PhD student Jeanie Kwok contributed to work on a MEMS device for cell stretching entitled "Biocompatible Optically Transparent MEMS for Micromechanical Stimulation and Multimodal Imaging of Living Cells" and is published in the Annals of Biomedical Engineering.