Nano-Bio-Imaging and Devices Laboratory

About the Lab

At the Lal Nano-Bio-Imaging and Devices Laboratory, we have two large thrusts in basic science and enabling technology development centered on our expertise in multiscale imaging and mechanics  with atomic force microscope (AFM). In parallel, we specialize in nanosensors and devices, including controlled on-demand theranostic delivery

In the past we have used the AFM-based multi modality imaging and functional mapping to study protein misfolding, cell-cell and cell-surroundings interactions. We also hope to further improve upon AFM design and application. By these efforts our goal is make AFM a common-place technology useful in the study of normal and pathophysiology, formation of preventive strategies, and characterization of therapeutics among other things. Recently we have expanded our capabilities in nanomaterial based carriers for biological applications

Recent Announcements

  • June News: Local high school students discover early detection of ovarian cancer.
    Our amazing high school students, Gitanjali and Priyanka, are on TV Channel 6 news on their work!

    Posted Jun 28, 2016, 11:19 PM by Joon Lee
  • Engineers develop a new biosensor chip for detecting DNA mutations
    Many news articles were released for our recent publication in PNAS 2016 (Hwang et al). Congratulations!
    Below is the link to the article from Jacob school of engineering.
    Engineers develop a new biosensor chip for detecting DNA mutations
    Posted Jun 28, 2016, 11:19 PM by Joon Lee
  • New Publications in the first half of 2016
    Congratulations to Alan GillmanJoon Lee, Nirave Patel, Alex Mo, Preston Landon, Woraphong Janetanakit, Michael Hwang, Karla Santacruz Gomez, David Alex Colburn, Samuel Dossou, Vrinda Sant, Paul Sud, Sid Akkiraju and Chen Zhang on their amazing work on these following publications in the first half of 2016!

    1. Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R. Computational Methods for Structural and Functional Studies of Alzheimer’s Amyloid Ion Channels. Protein Amyloid Aggregation: Methods and Protocols. 2016:251-68. DOI: 10.1007/978-1-4939-2978-8_16
    2. Santacruz-Gomez K, Silva-Campa E, Melendrez-Amavizca R, FT Arce, Mata-Haro V, Landon PB, Zhang C, Pedroza-Montero M, Lal R, Carboxylated Nanodiamonds Inhibit γ-Irradiation Damage of Human Red Blood Cells. Nanoscale 2016, 8, 7189–7196. DOI: 10.1039/C5NR06789H
    3. Feinstein HE, Benbow SJ, LaPointe NE, Patel N, Ramachandran S, Do TD, Gaylord MR, Huskey NE, Dressler N, Korff M, Quon B. Cantrell KL, Bowers MT, Lal R, and Feinstein SC. Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action. Journal of neurochemistry. 2016 Apr 1. DOI: 10.1111/jnc.13604
    4. Mo AH, Zhang C, Landon PB, Janetanakit W, Hwang MT, Santacruz Gomez K, Colburn DA, Dossou SM, Lu T, Cao YB, Sant V. Sud P, Akkiraju S, Shubayev V, Glinsky G, and Lal R. Dual-functionalized Theranostic Nanocarriers. ACS Applied Materials & Interfaces. 2016 May 4. DOI: 10.1021/acsami.6b02761
    5. Mo AH, Landon P, Gomez KS, Kang H, Lee J, Zhang C, Janetanakit W, Sant V, Lu T, Colburn DA, Akkiraju S. Dossou S.Cao Y.Lee KVarghese S,Glinsky G and Lal R.Magnetically-responsive Silica-gold Nanobowls for targeted delivery and SERS-based sensing. Nanoscale. 2016. DOI: 10.1039/C6NR02445A 
    6. Hwang M. T., Landon PB, Lee J, Choi D, Mo AH, Glinsky G, Lal R, Highly Specific SNP Detection Using 2D Graphene Electronics and DNA Strand Displacement. Proc. Natl. Acad. Sci. 2016. Doi: 10.1073/pnas.1603753113 (for press release check here)
    7. Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R, Small molecule NPT-440-1 inhibits ionic flux through Aβ1–42 pores: implications for Alzheimer’s disease therapeutics, Nanomedicine: Nanotechnology, Biology, and Medicine. 2016, DOI: 10.1016/j.nano.2016.06.001
    Posted Jul 6, 2016, 1:54 PM by Joon Lee
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