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Multiscale Biomechanics

We have used AFM and coupled techniques to study the mechanical properties of biological systems across multiple length scales.  Below are some areas and examples we have studied.

Endothelial barrier:

 F. Terán Arce, B. Meckes, S. M. Camp, J. G. Garcia, S. M. Dudek, R. Lal. "Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli" Nanomed.-Nanotechnol. 9 (7), 875-884 (2013).

 F. Terán Arce, J. L. Whitlock, A. A. Birukova, K. G. Birukov, M. F. Arnsdorf, J.G.N. García, R. Lal and S. Dudek. “Micromechanical Properties of Pulmonary Endothelial Barrier Enhancement Induced by Sphingosine-1 Phosphate: Regulation by Cortactin”. Biophys. J 95, 886-894 (2008).

A. A. Birukova, F. Terán Arce, N. Moldobaeva, S. Dudek, J.G.N. García, R. Lal, K. G. Birukov. “Endothelial permeability is controlled by spatially defined cytoskeletal force distribution: application of atomic force microscopy”. Nanomed.-Nanotechnol. 5, 30-41 (2009).

Hemichannels:

 F. Liu, F. Terán Arce, S. Ramachandran, R. Lal. “Nanomechanics of hemichannel conformations: connexin flexibility underlying channel opening and closing”. J Biol. Chem. 281, 23207-23217 (2006).

Bacteria/Biofilms:

 F. Terán Arce, R. Carlson, J. Monds, R. Veeh, F. Z. Hu, P. S. Stewart, R. Lal, G. D. Ehrlich, R. Avci. “Nanoscale structural and mechanical properties that influence pathogenicity of Haemophilus influenzae biofilms”. J. Bacteriol. 191, 2512-2520 (2009).