Research‎ > ‎

Nanomedicine

We are expanding into the use of nanomaterials and material properties for biological sensing, diagnosis and devices, and to understand structure and properties of biological systems and design artificial functional systems mimicking these biological systems

We have been pursing colloidal systems, DNA, and other smart materials in this area.

DNA:

  1. Mo, AH, Landon, PB, Meckes B, Yang M, Glinsky GV, Lal R, " On-demand Four-way Junction DNAzyme Nanoswitch Driven by Inosine-Based Partial Strand Displacement" Nanoscale(2014) 6 (3), 1462 - 1466Graphical abstract: An on-demand four-way junction DNAzyme nanoswitch driven by inosine-based partial strand displacement
  2. Landon PB, Lee J, Hwang MT, Mo AH, Zhang C, Neuberger A, Meckes B, Gutierrez JJ, Glinsky G, Lal R. " Energetically biased DNA motor containing a thermodynamically stable partial strand displacement state" Langmuir. 2014 Nov 25;30(46):14073-8.  doi: 10.1021/la503711
  3. Landon, PB; Ramachandran, S; Gillman, A, Yoon, TD; Lal ,R. DNA Zipper-based Tweezers. Langmuir,  2012, 28 (1), pp 534–540 online published, Sept 6, 2011.
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Colloidal Systems:

  1. Mo AH, Landon PB, Emerson CD, Zhang C, Anzenberg P, Akkiraju S, Lal R. "Synthesis of nano-bowls with a Janus template" Nanoscale. 2015 Jan 14;7(2):771-5. doi: 10.1039/c4nr05153j.Graphical abstract: Synthesis of nano-bowls with a Janus template

  2. Landon PB, Mo AH, Zhang C, Emerson CD, Printz AD, Gomez AF, DeLaTorre CJ, Colburn D, Anzenberg P, Eliceiri M, O'Connell C, Lal R. " Designing Hollow Nano Gold Golf BallsACS Appl Mater Interfaces. 2014 DOI: 10.1021/am502519x

    Abstract Image
  3. Kong, D.K., W. Zhang, J.H. Lee, K. Brammer, R. Lal, M. Karin, S. Jin. Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable Drug Release. Nano Letter 10, 5088–5092, 2010.
  4. Kong SD, Lee J, Ramachandran S, Eliceiri BP, Shubayev VI, Lal R, Jin S. "Magnetic targeting of nanoparticles across the intact blood-brain barrier." J Control Release. 2012 Nov 28;164(1):49-57. doi: 10.1016/j.jconrel.2012.09.021. Epub 2012 Oct 10.
On-demand drug release from SiMNCs. (A) TEM image showing trapped magnetic ...