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Laura Connelly



Education

Ph.D. Materials Science & Engineering, UCSD (current)

B.S. Materials Science & Engineering, Cornell University

Project: Defining and Refining High Resolution Imaging and Biomechanical Properties of Soft Matter

Research Interests: exploring the material properties of soft matter using atomic force microscopy to examine synthetic and natural lipid bilayers, proteins related to neurological diseases, hemichannels, and whole cells.

Email Address: lconnelly AT ucsd DOT edu

Graduate Awards/Fellowships

  1. UC San Diego Diversity Award, UCSD, 2013
  2. National Science Foundation Graduate Research Fellowship (NSF GRF), 2010-present
  3. National Defense Science and Engineering Graduate Fellowship (NDSEG), 2010-present
  4. Achievement Rewards for Collegiate Scholars (ARCS) Fellow, 2009-present
  5. UCSD Powell Fellow, UCSD, 2008-2011
Publications 
  1.  H. Jang, L. Connelly, F. Teran Arce, S. Ramachandran, R. Lal, B. Kagan, R. Nussinov, “Alzheimer’s disease: Which type of amyloid-preventing agents to emply?” Phys Chem. Chem. Phys., invited perspective, submitted January 2013.
  2. H. Jang, L. Connelly, F. Teran Arce, S. Ramachandran, B. Kagan, R. Lal, R. Nussinov, “Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane,” J. Chem. Theory Comp., (2012), 8 (3), pp 1143–1152. 
  3. Connelly L, Jang H, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, Lal R. ”Effects of Point Substitutions on the Structure of Toxic Alzheimer’s β-Amyloid Channels: Atomic Force Microscopy and Molecular Dynamics Simulations” Biochemistry. (2012) DOI:10.1021/bi300257e.
  4. Connelly L, Jang H, Teran Arce F, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov RLal R. ”Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology,” J Phys Chem B. 2012 ,11,(5):1728-35
  5. C. J. Frandsen, K. S. Brammer, K. Noh, L. S. Connelly, S. Oh, L. Chen, S. Jin, “Zirconium Oxide Nanotube Surface Prompts Increased Osteoblast Functionality and Mineralization,” Mat. Sci. Eng.C  31 1716-1722 (2011).
  6. K. S. Brammer, H. Kim, K. Noh, M. Loya, C. J. Frandsen, L. Chen, L.S. Connelly, S. Jin, “Highly Bioactive 8 nm Hydrothermal TiO2 Nanotubes Elicit Enhanced Bone Cell Response,” Adv. Eng. Mat. 13 [3] B88-B94 (2011).
  7. E. Herz, T. Marchincin, L. Connelly, D. Bonner, A. Burns, S. Switalski, U. Wiesner, “Relative Quantum Yield Measurements of Coumarin Encapsulated in Core-Shell Silica Nanoparticles,” J. Fluorescence 20 67-72 (2010).
  8. K. S. Brammer, C. Choi, S. Oh, C. J. Cobb, L. S. Connelly, M. Loya, S. D. Kong, S. Jin, “Antibiofouling, Sustained Antibiotic Release by Si Nanowire Templates,” Nano Lett. 9 [10] 3570-3574 (2009).

Presentations

  1. L. Connelly, R. Capone, H. Jang, S. Kotler, F. Teran Arce, S. Ramachandran, B. Kagan, R. Nussinov, R. Lal, “Amyloid Beta Ion Channels Mediate Alzheimer’s Toxicity and Site-Specific Substitution in the Pore Region Controls its Activity: Unraveling Therapeutic Targets by Atomic Force Microscopy, Electrophysiology, MD Simulation, and Protein Engineeiring,” Oral Platform, Society for Neuroscience, New Orleans, LA, October 2012.
  2. L. S. Connelly, F. Teran Arce, H. Jang, R. Capone, S. Kotler, B. Kagan, R. Nussinov, R. Lal, “Alzheimer’s β-Amyloid All-D-Enantiomers and Native All-L-Enantiomers Exhibit Similar Pore Structures in Lipid Bilayers: Atomic Force Microscopy,” Poster Presentation, 56th Annual Biophysical Society Meeting, San Diego, Ca, February 2012.
  3. H. Jang, R. Capone, S. A. Kotler, F. Teran Arce, L. Connelly, S. Ramachandran, B. L. Kagan, R. Lal, R. Nussinov, “Modeling Alzheimer’s Ion Channel Structures in Lipid Bilayers Formed by D- and L-Enantiomers of Beta-Amyloid (1-42) Peptide,” Poster Presentation, 56th Annual Biophysical Society Meeting, San Diego, Ca, February 2012
  4. R. Capone, H. Jang, S. A. Kotler, L. Connelly, M. Williams, S. Ramachandran, R. L. Kagan, R. Nussinov, R. Lal, “All D-Amino Acids Amyloid  β Forms Ion Channels in Lipid Bilayers and is Toxic to Cells,” 56th Annual Biophysical Society Meeting, San Diego, Ca, February 2012.
  5. L.Connelly, F. Teran Arce, H. Jang, R. Capone, S. Kotler, S. Ramachandran, B. Kagan, R. Nussinov, R. Lal, “Pore Structures in Lipid Bilayers Formed by an All-D-Enantiomer of Alzheimer’s β-Amyloid Are Similar to Those Formed by the Native L-Peptide,” Poster Presentation, MRS Fall Meeting & Expo, Boston, Ma, November 2011
  6. L. Connelly, K. Brammer, R. Lal, S. Jin, “Cellular Uptake, Cytotoxicity, and Morphological Changes of Mesenchymal Stem Cells by Magnetic Nanorods,” UCSD Graduate Student Research Expo, La Jolla, Ca, Poster Presentation, April 2011.
  7. L. Connelly, R. Capone, S. Kotler, H. Jang, R. Nussinov, R. Lal, “Probing Structural Features of Alzheimer’s β-Amyloid Ion Channels in Membranes Using Aβ Mutants,” ARCS Foundation Scientist of the Year Dinner, La Jolla, Ca, Poster Presentation, March 2011.
  8. R. Capone, S. A. Kotler, H. Jang, L.S. Connelly, R. Nussinov, R. Lal, “Probing Structural Features of Alzheimer’s β-Amyloid Ion Channels in Membranes Using Aβ Mutants,” 55th Annual Biophysical Society Meeting, Baltimore, MD, Oral Platform, March 2011.