News



Updates about lab personnel, new publications, and conferences.

December News!

posted Dec 5, 2017, 4:34 PM by Vrinda Sant   [ updated Dec 20, 2017, 11:15 PM ]

Press Release:
Experimental Drug Blocks Toxic Ion Flow Linked to Alzheimer’s Disease
"The first drug molecule that can regulate memory loss by directly blocking ions from leaking through nerve cell membranes."

A new drug, that stops ion flow in the brain, has been developed to potentially restore brain function and memory in a mouse model of Alzheimer's disease. 

This drug could be used to treat neurodegenerative diseases, such as Alsheimer's, Parkinson's and ALS. 

Read article!


In Situ Spatial Complementation of Aptamer-Mediated Recognition Enables Live-Cell Imaging of Native RNA Transcripts in Real Time

Let's split

An aptamer-initiated fluorescence complementation (AiFC) method was developed for RNA imaging by engineering a green fluorescence protein (GFP)-mimicking turn-on RNA aptamer into two split fragments that could tandemly bind to target mRNA. The use of AiFC enables the non-invasive, high-contrast real-time imaging of endogenous RNA molecules in living mammalian cells.




Multifunctional stimuli responsive polymer-gated iron and gold embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics
Targeted therapeutics: Using nanoparticle assemblies as drug carriers 

Magnetic and gold nanoparticles embedded in silica nanospheres (MGNSs) can be used for remotely targeted delivery of therapeutic molecules. The use of a magnetic field could guide MGNSs to specific anatomic locations, in particular hard-to-teach sites in the skeleton, and the use of multifunctional stimuli responsive polymer as a gate controls the drug release.

September News!

posted Sep 24, 2017, 1:32 PM by Joon Lee   [ updated Dec 20, 2017, 4:04 PM by Vrinda Sant ]

Publications
  • Wang L.*, Jang G.*, Ban D.*, Sant V.*, Seth J., Kazmi S., Patel N., Yang Q., Lee J., Janetanakit W., Wang S., Head B., Glinsky G, Lal R. Multifunctional Stimuli Responsive Polymer-Gated Iron and Gold-Embedded Silica Nano Golf Balls: Nanoshuttles for Targeted On-Demand Theranostics Nature Bone Research 2017 (DOI: 10.1038/boneres.2017.51) 

  • Hernandez A.M.*, Urbanke H.*, Gillman A.*, Lee J.*, Ryazanov S., Agbemenyah H.Y., Benito E., Jain G., Kaurani L., Grigorian G., Leonov A., Rezaei-Ghaleh N., Wilken P., Arce F.T., Wagner J., Fuhrman M., Caruana M., Camilleri A., Vassallo N., Zweckstetter M., Benz R., Giese A., Schneider A., Korte M.#, Lal R.#, Griesinger C.#, Eichele G.#, Fischer A.# The diphenylpyrazol compound anle138b blocks Abeta channels and rescues disease phenotypes in a mouse model for amyloid pathology. EMBO Molecular Medicine 2017. DOI: 10.15252/emmm.201707825 

  • Wang Z., Luo Y., Xie X., Hu X., Song H., Zhao Y., Shi J., Wang L., Glinsky G., Chen N., Lal R., Fan C. In-situ Spatial Complementation of Aptamer-mediated Recognition Enables Live-cell Imaging of Native RNA Transcripts in Real Time Angewandte Chemie 2017 doi: 10.1002/anie.201707795
Congratulations to Grace, Deependra, Vrinda, Jay Seth, Sami, Nirav, Qingqing, and Joon for their new publication!

August News!

posted Aug 3, 2017, 2:51 PM by Joon Lee   [ updated Dec 9, 2017, 3:42 PM by Vrinda Sant ]

Publications

Song P., Ye D., Zuo X., Li J., Wang J., Liu H., Hwang M. T., Chao J., Su S., Wang L., Shi J., Wang L., Huang W., Lal R., Fan, C. DNA Hydrogel with Aptamer-Toehold Based Recognition, Cloaking and Decloaking of Circulating Tumor Cells for Live Cell Analysis. Nano Lett. 2017. doi: 10.1021/acs.nanolett.7b01006

Congratulations to Michael for his new publication!!

July News!

posted Jul 29, 2017, 11:13 AM by Joon Lee   [ updated Dec 8, 2017, 1:42 PM by Vrinda Sant ]

Congratulations to Nirav, Grace, Malvika, Sami, Deependra for their new publication!

Janetanakit W., Wang L., Santacruz-Gomez K., Landon, P. B., Sud P. L., Patel N., Jang G., Jain M., Yepremyan A., Kazmi S., A., Ban D.K., Zhang F., and Lal R. Gold Embedded Hollow Silica Nano Golf Balls for Imaging and Photothermal Therapy. ACS Appl. Mater. Interfaces 2017. doi: 10.1021/acsami.7b08398

June News!

posted Jun 19, 2017, 11:38 AM by Joon Lee   [ updated Jul 29, 2017, 11:12 AM ]

Congratulations to Joon for his new publication!!

Li, N., Jang, H., Yuan, M., Li, W., Yun, X., Lee, J., Du, Q., Nussinov, R., Hou, J., Lal, R., Zhang, F. Graphite-Templated Amyloid Nanostructures Formed by A Potential Pentapeptide Inhibitor for Alzheimer’s Disease: A Combined Study of Real-Time Atomic Force Microscopy and Molecular Dynamics Simulations. Langmuir 2017. doi: 10.1021/acs.langmuir.7b00414

May News

posted May 19, 2017, 4:34 PM by Joon Lee   [ updated Dec 8, 2017, 1:43 PM by Vrinda Sant ]

Congratulations to Joon for his new publications!!

Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon–dielectric interactions, Nature Photonics 2017. DOI: 10.1038/nphoton.2017.74 
Check out here for press release as well.

Real-Time Visualization of Clustering and Intracellular Transport of Gold Nanoparticles by Correlative Imaging. Nature Communications. 2017, 8, 15646. doi: 10.1038/nphoton.2017.74

April News

posted May 19, 2017, 4:17 PM by Joon Lee   [ updated May 19, 2017, 4:29 PM ]

We welcome our new postdoc Deependra Kumar Ban, PhD. He is a structural biophysicist!

March News

posted Mar 6, 2017, 3:32 PM by Joon Lee

We welcome our new visiting scholar Prof. Rongzhang Hao. He is from Beijing Institute of Disease Control and Prevention.

February News

posted Feb 17, 2017, 1:03 PM by Joon Lee   [ updated Feb 23, 2017, 4:15 PM ]

Grace successfully passed her Comprehensive Exam. Congratulations!

Congratulations to Joon for his new publication in ACS Chemical Neuroscience!

Amyloid β Ion Channels in a Membrane Comprising of Brain Total Lipid Extracts. ACS Chem. Neurosci. 2017. DOI: 10.1021/acschemneuro.7b00006

January News

posted Feb 17, 2017, 12:45 PM by Joon Lee   [ updated Dec 8, 2017, 1:40 PM by Vrinda Sant ]

We welcome our new lab members!
Nathan Khosla, Jay Sheth, Xin Xu, Yushuang Liu, Akshat Saraf and Abhijith Karkisaval!

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